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A total of 42 cranes were 'choreographed' by their drivers during the Kranensee event - dubbed 'a ballet of cranes' - in the town of Aspern, Vienna in February, pictured.

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Antidepressants can have central and peripheral anticholinergic effects, as well as sedative effects, and can block the active reuptake of norepinephrine (NE), serotonin (5-HT), and dopamine.SSRIs are metabolized via the cytochrome P-450 system and may have drug interactions on that basis.Pros: An SNRI that’s generally well tolerated if started in low doses.Side effects: Can cause jitteriness, anxiety, insomnia; or can have the opposite effect (somnolence).The strategy behind rational drug development is to design a new drug that is capable of affecting a specific neural site of action (eg, uptake pumps, receptors) while avoiding effects on other site of actions.The goal in such development is to produce agents that are more efficacious, safer and better tolerated than older medications. Although all SSRI drugs have the same mechanism of action, each SSRI has slightly different pharmacological and pharmacokinetic characteristics.They have the advantage of ease of dosing and low toxicity in overdose.

Benzodiazepines should be avoided but, when necessary, may be used for a short duration or may be used long-term in patients for whom other treatments have failed.

The degree of enzyme inhibition varies among SSRIs.

Effects on blood levels and bioavailability of coadministered drugs, as well as pharmacodynamic interactions, account for most clinically significant SSRI-drug interactions.

There are a number of antidepressants available that work in slightly different ways and have different side effects.

Most work equally well to relieve depression, so choosing the right one generally involves subtle differences.